With the increase in the sensitivity of communities to environmental issues, activities such as corporate social responsibility, protection of natural environment, sustainable performance, and lean manufacturing have grabbed the attention of strategists and key stakeholders of companies. In other words, the environmental pollution has turned into one of the most important global challenges, and the waste processing companies have come to be known as prosperous and high added-value industries. The purpose of this study was to examine the effects of human resource management measures on green innovation through the mediating role of greet organizational culture. The statistical population of the study was comprised of the managers and office clerks of the waste processing companies in the industrial towns of Tehran province, out of which a sample of 165 individuals was selected based on Morgan’s table using proportionate stratified sampling. Questionnaires were used to measure the research variables. The reliability of questionnaires were confirmed using Cronbach’s alpha and combined reliability, and the obtained data was analyzed using statistical equation modeling and PLS software. The results of the study show that the green human resource management measures in the waste processing companies have positive, significant effects on green innovation both directly and through green organizational culture. The findings indicate that the purpose of implementing green human resource management measures is to train the staff in order to enhance their green abilities, skills, and knowledge and to encourage them to use these skills and abilities for the organizational purposes.